INCIDENCE AND PREDICTORS OF CLINICALLY SIGNIfiCANT ACUTE AND LATE TREATMENT-RELATED TOXICITY AFTER STEREOTACTIC RADIOSURGERY IN 4 OR MORE BRAIN METASTASES
نویسندگان
چکیده
Abstract AIMS Selected patients with multiple brain metastases can benefit from stereotactic radiosurgery (SRS). Brain V12 (total volume receiving 12Gy including target) predict for late toxicity in single target benign disease, however their value remains uncertain metastases. We report the incidence and evaluate predictors of 4 or more treated fraction SRS. METHOD 226 2160 2014-21 were retrospectively studied. Severe acute toxicity, symptomatic (new/progressive neurological symptoms ≥ 3 months post SRS) MRI changes suggestive treatment-effect analysed. Kaplan-Meier method cumulative function was used to assess survival respectively. RESULTS Median number per patient 6 (range 4-41) median 11.3cc 1.5- 45.2cc). overall (mos.) 7.6 months. Absolute grade 3/4 cerebral oedema/haemorrhage 4.9%. The subgroup developing SRS-related (16 patients) had a higher mos. than those without (25mos vs 5 mos., p <0.002). 9/16 (56%) developed Grade toxicity. 82/226 survived >12 this group 4% at 1 year 9.5% 2 years. CONCLUSIONS Within limits data available did not meaningfully SRS related clinically relevant <10% years despite accepting high treat these patients.
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ژورنال
عنوان ژورنال: Neuro-oncology
سال: 2023
ISSN: ['1523-5866', '1522-8517']
DOI: https://doi.org/10.1093/neuonc/noad147.021